Journal of Clinical Toxicology
Open Access

Toepfner N

Publications

• Case Report
  Toxic Optic Neuritis due to Isotretinoin in a Child with Neuroblastoma: A Case Report
  Author(s): Stächele J, Kokoschka M, Toepfner N, Smitka M, Bau V, Stedtler U, von der Hagen M and Suttorp M Stächele J, Kokoschka M, Toepfner N, Smitka M, Bau V, Stedtler U, von der Hagen M and Suttorp M
  
  Retinoids, namely tretinoin and isotretinoin, are metabolically active derivates of vitamin A and used as therapeutic agents. Tretinoin is part of the standard therapy for patients with acute promyelocytic leukemia. Isotretinoin is applied to children with medium and high risk neuroblastoma. Further, both isomers are frequently administered to patients with acne and other skin or mucosal disorders. Isotretinoin usage in dermatology has been associated with several ocular side effects. We report on the first pediatric patient with neuroblastoma who suffered from acute transient bilateral vision loss due to optic neuritis induced by systemical administration of isotretinoin. Therefore toxic optic neuritis needs to be considered as a potential adverse effect of isotretinoin therapy and weighed carefully against therapeutic benefits. By quantum mechanical calculations it could be shown th.. View More»
  DOI: 10.4172/2161-0495.1000241

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