Journal of Clinical & Experimental Dermatology Research
Open Access

Toshiharu Yamashita

Publications

• Review Article
  Wet Earwax Phenotype Determined by ABCC11 Polymorphism is a Highrisk Factor for Acne
  Author(s): Yasuyuki Sumikawa, Hitoshi Takahashi, Masuko Sumikawa, Kenji Kusatake, Sakae Kaneko, Toshiharu Yamashita and Eishin Morita Yasuyuki Sumikawa, Hitoshi Takahashi, Masuko Sumikawa, Kenji Kusatake, Sakae Kaneko, Toshiharu Yamashita and Eishin Morita
  
  Background: The type of earwax-wet or dry-is determined by a single nucleotide polymorphism (SNP)-538G>A (Gly180Arg)-in the ABCC gene (ABCC11), which encodes an ATP-binding cassette domain. Since axillary osmidrosis is closely related to earwax type, some dermatoses may be associated with earwax type. Objectives: We analyzed the association between the prevalence of a series of dermatoses and earwax phenotype. Further, we investigated ABCC11 localization in the skin. Methods: A total of 660 patients who visited Nopporo Dermatology Clinic in Hokkaido were enrolled in this study. The patients were interviewed to determine their earwax type-wet or dry-and a medical practitioner diagnosed dermatoses. The association between the prevalence of dermatoses and earwax type was analyzed statistically. ABCC11 localization in t.. View More»
  DOI: 10.4172/2155-9554.1000193

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