Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Toshio Kitawaki
Japan
Case Report
Diminished CD2 Expression in T cells Permits Tumor Immune Escape
Author(s): Momoko Nishikori, Toshio Kitawaki, Masaharu Tashima, Yayoi Shimazu, Minako Mori, Masakatsu Hishizawa, Tadakazu Kondo, Katsuyuki Ohmori and Akifumi Takaori-KondoMomoko Nishikori, Toshio Kitawaki, Masaharu Tashima, Yayoi Shimazu, Minako Mori, Masakatsu Hishizawa, Tadakazu Kondo, Katsuyuki Ohmori and Akifumi Takaori-Kondo
CD2 is an adhesion molecule present on the cell surface of T and natural killer (NK) cells, and its interaction with CD58 on antigen-presenting cells plays an important role in their immune reaction. Downregulation of CD58 is a frequent mechanism for immune escape in hematological malignancies, whereas there are very few reports that decreased CD2 expression in immune cells is associated with tumor development. We report here a patient who developed Epstein-Barr virus-associated lymphoproliferative disorder (EBV-LPD) along with diminished CD2 expression in T and NK cells. The patient exhibited severely decreased numbers of peripheral T cells and with Th2 cell-biased cytokine production. Although EBV-LPD was refractory to chemotherapy, the patient was treated successfully with allogeneic stem cell transplantation from a donor with normal CD2 expression. It is suggested that CD2-CD58 in.. View More»
DOI:
10.4172/2155-9899.1000406