Mycobacterial Diseases
Open Access

Toshio Kumasaka

Publications

• Research Article
  Calcified Granulomatous Lung Lesions Contain Abundant Mycobacterium tuberculosis Components
  Author(s): Tadatsune Iida, Keisuke Uchida, Nilufar Lokman, Asuka Furukawa, Yoshimi Suzuki, Toshio Kumasaka, Tamiko Takemura, Hiroshi Kawachi, Takumi Akashi and Yoshinobu EishiTadatsune Iida, Keisuke Uchida, Nilufar Lokman, Asuka Furukawa, Yoshimi Suzuki, Toshio Kumasaka, Tamiko Takemura, Hiroshi Kawachi, Takumi Akashi and Yoshinobu Eishi
  
  Mycobacterium tuberculosis can survive for a long time in the body of a healthy host, causing no symptoms after primary infection. Years or decades later, M. tuberculosis can be reactivated in some carriers, leading to symptoms of post-primary tuberculosis. During the asymptomatic period, M. tuberculosis is believed to survive in old foci of infection, yet these foci are uniformly negative by culture and acid-fast staining, which are conventional methods to detect mycobacteria. The precise location and amount of M. tuberculosis in these foci, therefore, are not well understood. Here we report that granulomatous lesions with calcification, a well-known characteristic of old tubercles, contained considerable amounts of M. tuberculosis genomes and cell wall components. These calcified lesions exhibited little inflammation but all were positive for M. tuberculosis by real-time polymerase .. View More»
  DOI: 10.4172/2161-1068.1000142

  Abstract PDF

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