Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Toshiyuki Yamamoto
Department of Dermatology, Fukushima Medical University,
Hikarigaoka 1, Fukushima 960-1295
Japan
Research Article
Crohn’s Disease and Mucocutaneous Conditions
Author(s): Toshiyuki YamamotoToshiyuki Yamamoto
Crohn’s disease is an immune-mediated disorder. Tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) produced by Th1 lymphocytes have traditionally been shown to be important in the pathogenesis of Crohn’s disease. In addition, recent studies demonstrate more complex cytokine networks, in which Th17 cells play a central role. The expansion and maintenance of Th17 cell responses require the activity of interleukin-23 (IL-23), and thus IL-23/IL-17 axis has been suggested to play a major role in the pathogenesis of Crohn’s disease. Crohn’s disease presents with various mucocutaneous signs, some of which show similar histological features of non-caseating granulomas with multinucleated histiocytes. Specific mucocutaneous manifestations include metastatic (cutaneous) Crohn’s disease, perianal fistula, and oral Crohn’s diseas.. View More»
DOI:
10.4172/2155-9554.S2-001