Pharmaceutical Analytical Chemistry: Open Access
Open Access

Tsai-Yueh Luo

Publications

• Research Article
  Liquid Chromatography-Mass Spectrometry to Monitor the Labeling Process Stability and Identify Derivatives during the Preparation of 188Re-MN-16ET: A Radiopharmaceutical for Hepatoma
  Author(s): Wei-Hsi Chen, Pei-Cheng Wang, Yu-Chieh Hsiao, Tsai-Yueh Luo and I-Chung Tang Wei-Hsi Chen, Pei-Cheng Wang, Yu-Chieh Hsiao, Tsai-Yueh Luo and I-Chung Tang
  
  The labeling process stability of a radiopharmaceutical, radio isotope rhenium-labeled N-[2-mercaptoethyl]- 3-aza-19-ethyloxycarbonyl-3-[2-mercaptoethyl] octadecanoate (188Re-MN-16ET) for treatment of hepatocellular carcinoma (HCC) from its precursor, triphenylmethyl (Ph3C-) group protected-MN-16ET with 188ReO4- was surveyed and identified the derivatives from both reactant and product. After incubation for various specified periods of up to 6 h under various labeling reaction conditions, including acetic acid or mixed with normal saline, room temperature or a reaction temperature of 100°C, and the radiolytic effect of Re-188, the levels of protected-MN-16ET and Re-MN- 16ET in solutions were analyzed by high performance liquid chromatography-tandem mass spectrometry (HPLCMS/ MS) to study the impacts of the labeling process on their structural stabilities and the derivativ.. View More»
  DOI: 10.4172/2471-2698.1000121

  Abstract PDF

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