Journal of Clinical & Experimental Dermatology Research
Open Access

Tulasi Ponnapakkam

Publications

• Research Article
  Treatment of Alopecia Areata in Mice by Stimulating the Hair Follicles Using Parathyroid Hormone Agonists Linked to a Collagen Binding Domain
  Author(s): Ranjitha Katikaneni, Tulasi Ponnapakkam, Rohan Gulati, Andrew A. Seymour and Robert Gensure Ranjitha Katikaneni, Tulasi Ponnapakkam, Rohan Gulati, Andrew A. Seymour and Robert Gensure
  
  Alopecia Areata is a patchy hair loss from autoimmune-mediated destruction of hair follicles, for which there is no adequate therapy. PTH-CBD is a fusion protein of parathyroid hormone and a bacterial collagen-binding domain, providing targeted delivery of a hair cycle stimulator to skin and promoting hair growth. Objectives: We tested the effects of PTH-CBD on hair growth in an established animal model for alopecia areata, the C3H/HeJ engrafted mouse. Methods: C3H/HeJ engrafted mice (Jackson Laboratories, Bar Harbor, ME) were treated subcutaneously for 8 weeks with either vehicle or different doses of PTH-CBD (320 mcg/kg x1, 1000 mcg/kg x1 or 1000 mcg/kg/wk). Results: Vehicle animals showed progressive hair loss, as expected. In PTH-CBD treated animals, grey scale quantification showed a greater proporti.. View More»
  DOI: 10.4172/2155-9554.10000307

  Abstract PDF

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