Journal of Cell Science & Therapy
Open Access

Umer Rashid

Publications

• Review Article
  DNA Methylation in Cancer Tissues
  Author(s): Daud Faran Asif, Naveed M and Umer Rashid Daud Faran Asif, Naveed M and Umer Rashid
  
  Cancer linked DNA hypo-methylation and hyper-methylation are present throughout the human genome. The hyper-methylation facilitates cancer progress by repressing the tumor suppressor gene. Hypo-methylation contribution towards cancer has not yet been clear. Recent studies of tissue specific methylation have suggested that DNA hypo-methylation aid tumor formation by many pathways. Loss of DNA methylation associated with cancer may alter transcription. In addition, DNA hypo-methylation might affect promoter usage production of intra-genic non-coding RNA transcripts, co-transcriptional splicing and initiation and elongation of transcription. Studies of hemi methylation of DNA in cancerous cells as well as normal tissues suggest that active de-methylation can explain cancer associated DNA hypo-methylation. New studies that genomic 5-hydroxymethylcytosine is intermediate in DNA de-methylat.. View More»
  DOI: 10.4172/2157-7013.1000272

  Abstract PDF

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