Journal of Chromatography & Separation Techniques
Open Access

Usmangani K Chhalotiya

Publications

• Research Article
  Quantification of Newer Anti-Cancer Drug Clofarabine in their Bulk and Pharmaceutical Dosage Form
  Author(s): Brijesh D Patel, Usmangani K Chhalotiya and Dhruv B Patel Brijesh D Patel, Usmangani K Chhalotiya and Dhruv B Patel
  
  Quantitative determination of Clofarabine in their Pharmaceutical Dosage form was carried out by Liquid chromatographic method. The aim of the present work was to develop a RP-HPLC method for Clofarabine (CFB). The column used was Luna C-18 column (250 mm × 4.6 mm id, 5 m particle size) using Water: Methanol (60:40 v/v) as a mobile phase at a flow rate of 1.0 ml/min. Quantification was achieved with UV detection at 266 nm over the concentration range 0.05-20 μg/ml and % recovery was found to be in the range of 99.58-100.95 for CFB by the RPHPLC method. The proposed method was validated with respect to linearity, accuracy, precision, selective, sensitive and robustness. The method was fruitfully applied for the estimation of clofarabine in injection dosage forms. .. View More»
  DOI: 10.4172/2157-7064.1000328

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