Journal of Bone Research

Journal of Bone Research
Open Access

ISSN: 2572-4916

+44 1478 350008

Uttam Kumar Nath

Uttam Kumar Nath

10/8, P. Majumder Road, Kayasthapara New Park Site, P.O. Haltu, Kolkata 700078, West Bengal
India

Publications
  • Case Report
    Hemophagocytic Lymphohistiocytosis Secondary to Salmonella paratyphi a Infection Presenting with Severe Pancytopenia and Multiorgan Dysfunction: The First Case Report
    Author(s): Uttam Kumar Nath, Nilanjan Sinha and Dibyendu De Uttam Kumar Nath, Nilanjan Sinha and Dibyendu De

    Hemophagocytic lymphohistiocytosis (HLH) or hemophagocytic syndrome is a life threatening hyperinflammatory condition caused by immune dysregulation and resulting in hemophagocytosis and organ damage by activated macrophages and histiocytes. The characteristic clinical features include fever, splenomegaly, cytopenias, liver dysfunction, and hyperferritinemia. HLH can be either primary (genetic), or secondary (acquired HLH) associated with infectious agents, autoimmune diseases, and malignancies. Majority of adult HLH cases are likely to be secondary to an underlying disease. The mortality rates in adults are high, and delayed diagnosis and multiorgan involvement are associated with poor prognosis. A high index of suspicion helps in early diagnosis, and prompt initiation of treatment is absolutely critical. A few cases of secondary HLH associated with .. View More»
    DOI: 10.4172/2329-8820.1000114

    Abstract PDF

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