Journal of Clinical and Cellular Immunology
Open Access

VA Varney

Publications

• Research Article
  The Deficiency of Serum Mannose Binding Lectin in Early Onset Idiopathic Pulmonary Fibrosis and Familial Cases
  Author(s): VA Varney, J Evans, H Parnell, B Bajardeen, A Nicholas, A Bansal and N SumarVA Varney, J Evans, H Parnell, B Bajardeen, A Nicholas, A Bansal and N Sumar
  
  Background: Idiopathic pulmonary fibrosis (UIP/IPF) is increasingly recognized that siblings & close blood relatives suggesting a genetic predisposition. Serum mannose binding lectin levels (MBL) forms part of the innate immune system with deficiency produces an opsonisation and phagocytosis defect. Serum levels are genetically determined. Aims & method: We examined the serum MBL in healthy controls (HC), frequently exacerbating COPD, pulmonary TB & Sarcoidosis along with UIP/IPF patients including those with and without an affected family member. Results: Mean serum MBL levels were not statistically different in HC, COPD or TB. Sarcoid had statistically higher mean levels. Those with IPF onset at <55 yrs old & those with affected blood relatives (FH) had significantly reduced levels compared with IPF onset >55 yrs and no other affected relative... View More»
  DOI: 10.4172/2155-9899.1000127

  Abstract PDF

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