Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Valeria Saraceni
Brazil
Research Article
Ascaris lumbricoides Co-Infection does not Alter Clinical Evolution of Pulmonary Tuberculosis nor Th1/Th2/Th17 Cytokine Profile but May Reduce Tissue Damage by Decreasing Il-6 Levels
Author(s): João Hugo Abdalla Santos, Samira Bührer-Sékula, Gisely Cardoso Melo, Marcelo Cordeiro-Santos, João Paulo Diniz Pimentel, Adriano Gomes-Silva, Allyson Guimarães Costa, Valeria Saraceni, Alda Maria Da-Cruz and Marcus Vinícius Guimarães LacerdaJoão Hugo Abdalla Santos, Samira Bührer-Sékula, Gisely Cardoso Melo, Marcelo Cordeiro-Santos, João Paulo Diniz Pimentel, Adriano Gomes-Silva, Allyson Guimarães Costa, Valeria Saraceni, Alda Maria Da-Cruz and Marcus Vinícius Guimarães Lacerda
Immunological control of Mycobacterium tuberculosis (MTB) infection is dependent on the cellular immune response, mediated predominantly by Th1 type CD4+ T cells. Polarization of the immune response to Th2 can inhibit the host immune protection against pathogens. Patients with tuberculosis (TB) co-infected with helminths show more severe pulmonary manifestations, a deficiency in the immune response against TB and an impaired response to anti-TB therapy. We evaluated the cellular immune response and the impact of the presence of Ascaris lumbricoides (Al) on the immune and clinical response in pulmonary TB patients. Ninety-one total individuals were included: 38 TB patients, 11 TB patients coinfected with Al and other helminths, 10 Al patients, and 34 non-infected control individuals. Clinical evolution of pulmonary tuberculosis was studied on 0, 30, 60, and.. View More»