Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Valerio Pravettoni
Italy
Short Communication
Investigating the Changes in Venom-Specific IgE Induced by Wasp Venom Immunotherapy
Author(s): Valerio Pravettoni, Cristoforo Incorvaia, Marta Piantanida and Erminia RidoloValerio Pravettoni, Cristoforo Incorvaia, Marta Piantanida and Erminia Ridolo
Patients with systemic reactions (SR) to Hymenoptera stings are successfully treated by venom immunotherapy (VIT), but there is not yet a general agreement on the criteria for stopping VIT. We discuss the importance of the venom-specific IgE levels among these criteria. In particular, the results from a recent study evaluating the IgE changes during a 5-year VIT, in patients stung and protected within the first 3 years (SP 0-3) or in the last 2 years (SP 3-5), and in patients not stung (NS) are considered. A total of 232 yellow jacket venom (YJV) allergic patients were included and divided into the following groups: 84 NS, 72 SP 0-3 and 76 SP 3-5. IgE levels decreased during VIT compared to baseline values (χ2=346.029, p<0.001). Recent vespid stings accounted for significantly higher IgE levels despite clinical protection. IgE levels after 5 years of VIT correlated significant.. View More»
DOI:
10.4172/2155-9899.1000416