Translational Medicine
Open Access
ISSN: 2161-1025
ISSN: 2161-1025
Venu K. Thirukonda
Tanzania
Research Article
Aberrant Methylation in Hematological Malignancies
Author(s): Venu K. Thirukonda, Radha Raghupathy and Samir ParekhVenu K. Thirukonda, Radha Raghupathy and Samir Parekh
Epigenetics encompasses heritable changes in gene expression without alterations in genetic sequence. Among the multiple epigenetic regulators of gene expression, methylation of cytosine in genomic DNA is amongst the most stable and best studied. Expanding knowledge of aberrant methylation in hematological malignancies has increased its applicability in diagnosis, classification, prognostication and prediction of treatment response. Genome-wide methylation profiling can differentiate between clinically relevant subtypes of non-hodgkin’s lymphoma (NHL) as well as distinguish monoclonal gammopathy of unknown significance (MGUS) from multiple myeloma (MM). New subcategories of normal karyotype acute myeloid leukemia (AML) with distinct canonical pathways and different disease behavior have also been identified by methylation studies. Methylation scores can predict outcomes in chron.. View More»
DOI:
10.4172/2161-1025.S1-004