Journal of Clinical & Experimental Dermatology Research
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Viana DC

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• Research Article
  Evaluation of Tumor Growth in Treatment of Murine Melanoma by Transdermal Infusion of Etoposide by Radiofrequency
  Author(s): Salomao-Junior A, D’Agostino LG, Luna ACL, Menezes FC, Viana DC, Rodrigues CJ and Maria DA Salomao-Junior A, D’Agostino LG, Luna ACL, Menezes FC, Viana DC, Rodrigues CJ and Maria DA
  
  Objective: In order to make such a substance cross the epidermal barrier, was utilized a method of transdermal drug delivery system (TDDS) combined with the chemotherapeutic etoposide in the treatment of dorsal melanoma B16F10 tumor on C57BL/6J mice. Methods: The treatment groups were as follows: etoposide followed by radiofrequency (RF); RF followed by etoposide; etoposide and controls. The animals were treated with delivery interval of 72 hours, for 20 days and were analyzed the tumor growth; weight and hematological profile. The histological analysis and cell cycle by flow cytometry were performed after end of the treatment period. Results: The tumors treated with RF followed by etoposide showed slower growth compared to the tumors treated with etoposide followed by RF, and found that treatment with radiofrequency con.. View More»
  DOI: 10.4172/2155-9554.1000325

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