Advanced Techniques in Biology & Medicine
Open Access

Vidya Jha

Publications

• Research Article
  Metagenomic Analysis of Molecular Profile of Breast Cancer Using Genie a Literature Based Gene Prioritizing Tool: A Novel Approach
  Author(s): Amit Kumar Yadav and Vidya Jha Amit Kumar Yadav and Vidya Jha
  
  Background: The biological complexity and heterogeneity of breast cancer can be explained by molecular profile. Microarray technique is the method of choice to study it. But there are certain limitations. Computational techniques are a novel method to study gene expression profile. Materials and method: Genie, a freely available web based software was used to analyze literature, gene and homology information from MEDLINE, NCBI Gene and HomoloGene databases. Inputs given were target species (Homo sapiens) and biomedical topic (breast cancer). According to input provided genes of target species are prioritized. Results: The ranking given to 1906 reported genes was not along expected lines. Therefore, they were manually re-ranked according to number of hits. These were narrowed to 70. The proteins encoded by these gen.. View More»
  DOI: 10.4172/2379-1764.1000147

  Abstract PDF

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