Journal of Proteomics & Bioinformatics
Open Access

Vladislav V. Khrustalev

Publications

• Research Article
  Main Pathways of Proteome Simplification in Alphaherpesviruses Under the Influence of the Strong Mutational GC-pressure
  Author(s): Vladislav V. Khrustalev and Eugene V. Barkovsky Vladislav V. Khrustalev and Eugene V. Barkovsky
  
  The simplification of amino acid content distribution under the influence of the strong mutational pressure takes place in simplex and varicello viruses proteins coded by genes with GC-content higher than 60%. We proved this statement by the way of in-silico calculation of Shannon’s entropy of amino acid content distribution in all proteins from ten completely sequenced simplex and varicello viruses. Entropy of amino acid content distribution decreases because of the growth of GARP (glycine, alanine, arginine and proline) usage due to the decrease not only in FYMINK (phenylalanine, tyrosine, methionine, isoleucine, asparagine and lysine) but also in other amino acids (coded by codons with average GC-content) usages. Threonine, serine, glutamine and cysteine are frequently substituted to GARP in proteins coded by genes with G+C higher than 60% (threonine and seri.. View More»
  DOI: 10.4172/jpb.1000065

  Abstract PDF

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