Journal of Clinical Toxicology
Open Access

VS Negi

Publications

• Research Article
  Detection of Retinal Changes in Patients on Long Term Chloroquine/Hydroxy Chloroquine Therapy Using Optical Coherence Tomography
  Author(s): Pratyusha G, Shashi Ahuja and VS NegiPratyusha G, Shashi Ahuja and VS Negi
  
  Background: The best technique to diagnose chloroquine/ hydroxychloroquine-induced retinopathy changes at the earliest remains ambiguous at present. In this study, we evaluated the time-domain optical coherence tomography (OCT) to identify retinal changes associated with chloroquine and hydroxychloroquine. Methods: One hundred patients with immunological diseases were included in the study. Fifty of them had been on chloroquine and/or hydroxychloroquine therapy for at least five years and the other 50 patients as controls. Detailed ophthalmic examination including Amsler grid , colour vision , automated threshold white perimetry using 10-2 protocol on Humphrey field analyzer, fluorescein angiography when indicated and time domain Optical Coherence Tomography was done. Results: A statistically significant thinning was n.. View More»
  DOI: 10.4172/2161-0495.1000201

  Abstract PDF

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