ISSN: 2161-1017
+44 1478 350008
Waleed S. Mohamed
Taif College of Medicine,
Egypt
Research Article
Role of Ghrelin, Leptin and Insulin Resistance in Development of Metabolic Syndrome in Obese Patients
Author(s): Waleed S. Mohamed, Mohammed A. Hassanien and Khalid EL Sayed Abokhosheim
Waleed S. Mohamed, Mohammed A. Hassanien and Khalid EL Sayed Abokhosheim
Objective: Obesity and its complications including metabolic syndrome (MetS) have been increased in children and adolescents recently. Leptin is known to play an important role in the pathogenesis of obesity. The objective of this study was to evaluate the relationship between Leptin, Ghrelin and Insulin resistance in the development of metabolic syndrome in obese persons.
Methods: this study was carried out on fifty obese persons. All patients have BMI ≥ 30 Kg/m2. Twenty of them have metabolic syndrome. Body Mass Index (BMI), Waist Circumference (WC), and blood pressure were measured. Fasting Plasma Glucose (FBG), two hours Post Prandial Blood Glucose (PPBG), Glycated hamoglobin A1C (HbA1c), triglyceride (TG), Total Cholesterol (TC), high and low density lipoprotein cholesterol (HDL-C and LDL-C), serum Leptin, Ghrelin and Insulin were do.. View More»
DOI:
10.4172/2161-1017.1000122