ISSN: 2572-0775
Wang Fengyu
China
Research Article
The Changes of the Levels of Tumor Necrosis Factor α, Interferon γ and Vascular Endothelial Growth Factor in the Sera of Children with Acquired Aplastic Anemia after Blood Transfusion
Author(s): Li Yuyun, Li Ying, Zhang Haixia, Yan Guangxing, Xu Feng, Jia Zhiyi, Wang Fengyu, Zhang Yu, Xue Yuanyuan, Wang Lingzi, Chao Chunxia, Ma Liji, Zhang Xiaoyue and Bi FangjieLi Yuyun, Li Ying, Zhang Haixia, Yan Guangxing, Xu Feng, Jia Zhiyi, Wang Fengyu, Zhang Yu, Xue Yuanyuan, Wang Lingzi, Chao Chunxia, Ma Liji, Zhang Xiaoyue and Bi Fangjie
Objective: To discuss how blood transfusion affects the progression of acquired aplastic anemia by assaying the levels of TNF-α, IFN-γ and VEGF in the sera of children with acquired aplastic anemia both before and after blood transfusion
Methods: In the study, the sera of 15 children with acquired aplastic anemia were collected both before and one or two days after blood transfusion. And during the study period the sera of 12 normal children who had body checkups in our hospital were also collected. The levels of TNF-α, IFN-γ and VEGF in the sera of children were assayed by the method of ELISA with the corresponding kits.
Results: The levels of TNF-α and IFN-γ in the sera of children with acquired aplastic anemia were 2.29 ± 0.36 ng/L and 21.30 ± 9.12 ng/L respectiv.. View More»
DOI:
10.4172/2572-0775.1000140