Pharmaceutical Analytical Chemistry: Open Access
Open Access

Wei Li

Publications

• Research Article
  Brain Metabolomics Study on the Protective Effects of Ginsenosides Rg1 and Rb1 in an Alzheimers Disease Mouse Model
  Author(s): Naijing Li, Ling Zhou, Wei Li, Ying Liu, Xiu Gu, Yang Peng and Ping He Naijing Li, Ling Zhou, Wei Li, Ying Liu, Xiu Gu, Yang Peng and Ping He
  
  Alzheimer’s disease (AD) is a serious neurodegenerative disease in aging populations with no effective method for the diagnosis or for the treatment. Although some physiological and pathological functional parameters have been studied, little knowledge about the changes of small metabolites in biofluids has been reported, which may result in poor diagnosis and treatment for AD. Ginsenoside Rg1 and Rb1, the pharmacologically active ingredients of ginseng, were known to have anti-AD effects, while, their mechanism remain unclear completely. This study was designed to explore globally metabolomic character of AD induced by Aβ1-42 in brain and the holistic efficacy of ginsenoside Rg1 (GRg1) and ginsenoside Rb1 (GRb1) on AD. Morris water maze was performed to examine the behavioral changes in mice. Global metabolic profiling with UPLC/MS (ultra-high-performance liquid chromatogr.. View More»
  DOI: 10.4172/2471-2698.1000108

  Abstract PDF

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