Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Wei Shen
Tanzania
Research Article
Therapeutic Potential of Topical Fenofibrate Eyedrops in Diabetic Retinopathy and AMD Rat Models
Author(s): Boyu Lu, Yang Gao, Wei Shen, Qingjiong Zhang, Yang Hu and Ying ChenBoyu Lu, Yang Gao, Wei Shen, Qingjiong Zhang, Yang Hu and Ying Chen
Objective: Diabetic retinopathy (DR) combined with age-related macular degeneration (AMD) is the leading cause of blindness in the US. Here, we report the efficacy of topical application of fenofibrate, an anti-lipid drug, in the treatment of retinal inflammation and neovascularization in rat models of DR and wet AMD, and in order to propose its use as a revolutionary therapy for ocular microvascular diseases.Research design and methods: Fenofibrate was topically administered to rats. Following administration, the bioavailability of fenofibrate and its activated metabolite, fenofibric acid, in the retina, liver, and serum was determined using mass spectrometry. The effects of topical fenofibrate on retinal vascular leakage and inflammation were assessed using vascular permeability and leukostasis assays in streptozotocin (STZ)-induced diabetic r.. View More»
DOI:
10.4172/2155-9570.1000347