Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Wei Yang
Rm. 4009, Davis Research Bldg, Cedars- Sinai Medical Center,
8700 Beverly Blvd, Los Angeles, CA 90048
Tanzania
Review Article
Technologies and Challenges in Proteomic Analysis of Protein S-acylation
Author(s): Bo Zhou, Mingrui An, Michael R Freeman and Wei YangBo Zhou, Mingrui An, Michael R Freeman and Wei Yang
Protein S-acylation (also called palmitoylation) is a pervasive post-translational modification that plays critical roles in regulating protein trafficking, localization, stability, activity, and complex formation. The past decade has witnessed tremendous advances in the study of protein S-acylation, largely owing to the development of novel S-acylproteomics technologies. In this review, we summarize current S-acylproteomics approaches, critically review published S-acylproteomics studies, and envision future directions for the burgeoning S-acylproteomics field. Emerging S-acylproteomics technologies promise to shed new light on this distinct post-translational modification and facilitate the discovery of new disease mechanisms, biomarkers, and therapeutic targets... View More»
DOI:
10.4172/jpb.1000327