Biochemistry & Pharmacology: Open Access
Open Access

Wei Zheng

Publications

• Research Article
  Iguratimod Synergizes with Methotrexate to Exert Anti-Inflammatory and Bone-Protective Effect and Block the Progression of Collagen-Induced Arthritis in Mices
  Author(s): Qiang Xu Qiang Xu
  
  Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic synovial inflammation and disability. The most widely used Disease-Modifying Antirheumatic Drug (DMARD) is methotrexate and it continues to be the gold standard. However, the use of high-dose methotrexate is associated with severe adverse effects. Iguratimod, which is currently used in clinics in China and Japan, is a novel oral DMARD for the treatment of RA. In this study, the effect of combination of methotrexate and iguratimod on murine Collagen-Induced Arthritis (CIA) and its mechanism was determined. Oral administration of iguratimod (3 mg/kg, 10 mg/kg) combined with methotrexate (1 mg/kg) potently blocked CIA development and delayed its progression, which was stronger than iguratimod or methotrexate used alone. Furthermore, infiltration of inflammatory cel.. View More»
  DOI: 10.4172/2167-0501.1000135

  Abstract PDF

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