Angiology: Open Access

Angiology: Open Access
Open Access

ISSN: 2329-9495

+44 1478 350008

Wen G Jiang

Wen G Jiang
Cardiff University-Peking University Cancer Institute, Cardiff University School of Medicine,
Cardiff, CF14 4XN
United Kingdom

Publications
  • Research Article
    Knockdown of AAMP Impacts on HECV Cell Functions In Vitro and Affects the Expression of VE-Cadherin
    Author(s): Yukun Yin, Andrew J Sanders, Li Feng and Wen G Jiang Yukun Yin, Andrew J Sanders, Li Feng and Wen G Jiang

    Background: Angio-Associated Migratory Cell Protein (AAMP) is a 52 kDa protein expressed in a variety of human cell lines. Previous studies have demonstrated that AAMP is involved in endothelial cell adhesion, migration, and tube formation and plays roles in signalling pathways, such as RhoA-ROCK Methods: In this study, we knocked down the expression of AAMP in HECV cells using hammerhead ribozymes and assessed the influence of AAMP on endothelial cells. In order to explore potential mechanisms, Wnt/β catenin inhibitors (FH535 or IWP2) were also used in a number of the functional assays and the immunofluorescent staining patterns of several key molecules were explored. Results: Knockdown of AAMP expression was observed in the HECV cell line following transfection with the ribozyme transgene. Cellular migration.. View More»
    DOI: 10.4172/2329-9495.1000125

    Abstract PDF

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