Translational Medicine
Open Access

Wenwei Zhu

Publications

• Research Article
  CD8+ T Cells Are Compromised In Human Pancreatic Cancer
  Author(s): Xianjun Yu, Shunrong Ji, Jin Xu, Wantong Yao, Bin Qu, Wenwei Zhu, Wenyan Xu, Bo Zhang and Yongfeng Xu Xianjun Yu, Shunrong Ji, Jin Xu, Wantong Yao, Bin Qu, Wenwei Zhu, Wenyan Xu, Bo Zhang and Yongfeng Xu
  
  Objectives and background: An efficient cellular immune response against cancer requires a robust population of CD8+ T cells with optimal cytotoxic functions. The aim of this study was to define the percentage of CD8+ T cells and the perforin expression level of the CD8+ T cells in the peripheral blood from patients with pancreatic adenocarcinoma. Methods: Fourty-six pancreatic cancer patients in our center between August 2011 and April 2012 were recruited. Thirty-five healthy persons were included as controls. Blood was drawn before surgery and one and a half months after surgery. Cells were labeled with monoclonal antibodies against perforin and surface antigen CD8 and were analyzed by flow cytometry. Results: Compared with the healthy controls, the percentage of CD8+ T cells was significantly decreased in pancreatic cancer patients. The level of perforin expression was also decreas.. View More»
  DOI: 10.4172/2161-1025.1000105

  Abstract PDF

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