Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-77-2385-9429
ISSN: 2157-7609
+44-77-2385-9429
Wen-Xing Ding
Toxicology and Therapeutics, The University of Kansas Medical Center,
MS 1018 3901 Rainbow Blvd, Kansas City, 66160
Tanzania
Editorial
Autophagy in Toxicology: Defense against Xenobiotics
Author(s): Wen-Xing Ding
Wen-Xing Ding
Autophagy is a lysosomal degradation pathway that can degrade cellular proteins and damaged organelles to maintain cellular homeostasis. It is generally agreed that autophagy is a cellular protective mechanism against cell death, but in certain cases, it has been reported that autophagy also contributes to cell death. Although the role of autophagy in toxicology has not been extensively studied, I here discuss the current knowledge regarding the role of autophagy in xenobiotic-induced cell death. I also discuss the role of autophagy in the regulation of redox homeostasis and tumorigenesis... View More»
DOI:
10.4172/2157-7609.1000e108