Family Medicine & Medical Science Research
Open Access

Wim Moosdorff

Publications

• Research Article
  Prospective Studies on Diagnosis, Prevention, and Management of Deep Vein Thrombosis (DVT), DVT Recurrence and the Post-Thrombotic Syndrome (PTS): From Concept to Study Design in the Primary Care Setting
  Author(s): Jan Jacques Michiels, Janneke M Michiels, Wim Moosdorff, Hannie Maasland, Mildred U Lao, Arie Markel and Martino Neumann Jan Jacques Michiels, Janneke M Michiels, Wim Moosdorff, Hannie Maasland, Mildred U Lao, Arie Markel and Martino Neumann
  
  The requirement for a safe diagnostic strategy of deep vein thrombosis (DVT) should be based on an overall objective post incidence of venous thromboembolism (VTE) of less than 1% during 3 months follow-up. Compression ultrasonography (CUS) of the leg veins has a negative predictive value (NPV) of 97% to 98% indicating the need of repeated CUS testing within one week. A sensitive ELISA VIDAS safely excludes DVT and VTE with a NPV between 99 and 100% when the clinical score is low to zero. The combination of low clinical score and a less sensitive D-dimer test (Simply Red or Simplify) is not sensitive enough to exclude DVT and VTE in routine daily practice. From prospective clinical research studies it may be concluded that complete recanalization within 3 months and no reflux is associated with a low or no risk of PTS obviating the need of MECS 6 months after DVT. Partial and complete.. View More»
  DOI: 10.4172/2327-4972.1000138

  Abstract PDF

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