Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Xia Jin
Institut Pasteur of Shanghai, Chinese Academy of Sciences,
320 Yueyang Road, Shanghai 200031
China
Review Article
The Role of CD4+ T cells in the Development of an Efficacious HIV Vaccine
Author(s): Haitao Liu, Wei Shen, Jiayi Shu and Xia JinHaitao Liu, Wei Shen, Jiayi Shu and Xia Jin
HIV infection has caused serious public health disaster during the past three decades. The rapid discovery of antiretroviral drugs and the implementation of combination antiretroviral therapy in many countries over the past two decades have led to a marked decrease in HIV-associated mortality and morbidity. However, the antiretroviral therapy alone has been unable to eradicate the virus from HIV-infected individuals. To reduce the incidence of HIV infection on a global scale, vaccine is still the most cost-effective method. Due in part to the lack of a comprehensive understanding of immune correlates of protection, an effective HIV vaccine has not yet been developed. Since CD4+ T cells play a central role in orchestrating various arms of immune responses, vaccines that mobilize CD4+ T cells should help to elicit desired immune responses for the prevention of HIV .. View More»
DOI:
10.4172/2155-9899.1000350