Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Xiao-Dong Yuan
China
Research Article
Expression Characteristics of Surface Markers of Memory T cells, CD45RO, CCR7 and CD62L, in Tumor-infiltrating Lymphocytes in Liver Cancer Tissues of Patients with Hepatocellular Carcinomas
Author(s): Yong Xie, Bi-Wei Luo, Xiao-Dong Yuan, Pei-Kai Tian, Xi Ou, Ze-Wei Lin, Xiao-Ping Liu and Ji-Kui LiuYong Xie, Bi-Wei Luo, Xiao-Dong Yuan, Pei-Kai Tian, Xi Ou, Ze-Wei Lin, Xiao-Ping Liu and Ji-Kui Liu
Purposes: To investigate expression of surface markers on memory T cells and distribution of T cell subsets among tumor-infiltrating lymphocytes (TILs) in liver of hepatocellular-carcinoma (HCC) patients.Methods: TILs from liver tumor and paracancerous tissue (PT) of 30 HCC patients and 30 subjects who were performed hepatectomy due to benign pathogenic lesion (control) were stained with anti-CD3, CD4, CD8, CD45RO, CD62L and CCR7 antibodies. The distribution of four T cell subsets, CD45RO+CD62L+CCR7+T (central memory T cells, TCM), CD45RO+CD62L-CCR7-T (effector memory T cells, TEM), CD45RO+ CD62L+CCR7-T (CCR7-T) and CD45RO+ CD62L-CCR7+T (CCR7+T), among TILs was measured with polychromatic flow .. View More»
DOI:
10.4172/2155-9899.1000181