Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Xiao-Ping Zhong
Rm 133 MSRB, Research Drive, Box 2644, Durham, NC 27710
Tanzania
Review Article
T cell Receptor Signal Transduction in T lymphocytes
Author(s): Balachandra K Gorentla and Xiao-Ping ZhongBalachandra K Gorentla and Xiao-Ping Zhong
The T cell receptor (TCR) recognizes self or foreign antigens presented by major histocompatibility complex (MHC) molecules. Engagement of the TCR triggers the formation of multi-molecular signalosomes that lead to the generation of second messengers and subsequent activation of multiple distal signaling cascades, such as the Ca+2-calcineurin-NFAT, RasGRP1-Ras-Erk1/2, PKCθ-IKK-NFκB, and TSC1/2-mTOR pathways. These signaling cascades control many aspects of T cell biology. Mechanisms have been evolved to fine-tune TCR signaling to maintain T cell homeostasis and self-tolerance, and to properly mount effective responses to microbial infection. Defects or deregulation of TCR signaling has been implicated in the pathogenesis of multiple human diseases... View More»
DOI:
10.4172/2155-9899.S12-005