Journal of Applied Pharmacy
Open Access

Xu L

Publications

• Research Article
  Study of the Intestinal Absorption Characteristics of Curcumin In Vivo and In Vitro
  Author(s): Xue M, Cheng Y, Xu L and Zhang L Xue M, Cheng Y, Xu L and Zhang L
  
  Curcumin is the yellow pigment of turmeric. In addition to its positive safety profile, curcumin is reported to have beneficial pharmacologic effects as an antioxidant, antitumor, and anti-inflammatory agent, along with other promising pharmacologic effects on the cardiovascular and digestive systems. Curcumin is poorly absorbed, which limits its value in clinical application. In order to improve the poor bioavailability and enhance the pharmacologic action of curcumin, we studied its absorption mechanisms in an animal model in vivo and in a Caco-2 cell model in vitro. The absorption rates of curcumin at different concentrations in blank intestinal juice were not the same. The absorption rate of curcumin solution at a concentration of 5 μg/mL was the highest, followed by 10 μg/mL, and the minimum absorption occurred at 20 μg/mL. The absorption rate in the il.. View More»
  DOI: 10.21065/1920-4159.1000246

  Abstract PDF

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