Pancreatic Disorders & Therapy
Open Access

Xue-Feng Lu

Publications

• Research Article
  Ethyl Pyruvate Inhibits Pancreatic Tumor Growth in Mice
  Author(s): Qian-Qian Li, Xue-Feng Lu, Chong-Qi Jia, Xu-Yang Liang, Jun-Ying Jia, Ke-Qiang Yan and Bao-Quan Cheng Qian-Qian Li, Xue-Feng Lu, Chong-Qi Jia, Xu-Yang Liang, Jun-Ying Jia, Ke-Qiang Yan and Bao-Quan Cheng
  
  Abstract Objective: We evaluate the anti-tumor effect of Ethyl Pyruvate (EP) on the human pancreatic cancer xenograft in nude mice. Methods: Human pancreatic cancer cell line SW1990 was used in vivo to investigate the effect of EP on the human pancreatic cancer in mice. The mice were treated with different doses of EP (100 mg/kg, 50 mg/kg, i. p. ) initiating 1 hour (early treatment) after tumor cells injection daily for 14 days, and EP (100 mg/kg, i. p. ) was administered beginning12 days (delayed treatment) after tumor cells injection daily for 14 days. Tumor volumes were measured. ELISA was used to measure tumor necrosis factor (TNF) -α, interleukin (IL) -1β, IL-6 and high mobility group box 1 (HMGB1). Results: EP administration inhibited pancreatic tumor growth significantly. The differences in tumor volumes were statistical significant (P=0.0001) and in tumor weights (P.. View More»
  DOI: 10.4172/2165-7092.1000104

  Abstract PDF

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