Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Yan Wang
China
Research Article
β-Tubulin is a Predictive Marker of Docetaxel Combined with S-1 in Recurrent or Metastatic Gastric Cancer
Author(s): Yuehong Cui, Rongyuan Zhuang, Qian Li, Shan Yu, Yiyi Yu, Yi Feng, Yan Wang, Xi Guo and Tianshu Liu
Yuehong Cui, Rongyuan Zhuang, Qian Li, Shan Yu, Yiyi Yu, Yi Feng, Yan Wang, Xi Guo and Tianshu Liu
Aim: The aim of this study was to evaluate efficacy and toxicity of low dose of docetaxel in combination with standard dose of S-1 for patients with recurrent or metastatic gastric cancer, and to investigate whether β-tubulin protein expression level is a predictive or prognostic factor. Methods: From March 2010 to December 2011, 90 patients from Medical Oncology Department of Shanghai Zhongshan Hospital, Fudan University, were enrolled in this study. Patients with recurrent or metastatic gastric adenocarcinoma were treated with docetaxel of 40 mg/m2 intravenously on day 1 and S-1 of 80 mg/m2 orally for 14 days with one-week intermission as first-line chemotherapy. The chemotherapeutic effects were evaluated every 3 cycles using the Response Evaluation Criteria In Solid Tumors (RECIST1.1). The tumor tissues and the serum of peripheral blood were obtained at the start of the study.. View More»
DOI:
10.4172/2167-7700.1000132