ISSN: 2167-7700
+44 1223 790975
Yang HA
IR Iran
Research Article
Claudin-7 Mediated Metastasis of Human Lung Adenocarcinoma Cells in
Intermittent Hypoxia
Author(s): Liu H, Li JY, Wang Y, Yang HA, Sun XY, Hu Y and Yan AHLiu H, Li JY, Wang Y, Yang HA, Sun XY, Hu Y and Yan AH
Metastasis is a prerequisite for cancer development, which requires both proliferation and migration/invasion of the cancer cells. In this study, we reported that severe hypoxic conditions could inhibit the expression of HIF-1α and Claudin-7 and up-regulate the expression of p18 in human lung adenocarcinoma cells (A-549 cells). We demonstrated that hypoxic conditions can promote the metastasis, while inhibit the viability and proliferation of A-549 cells by downregulating HIF-1α/Claudin-7 and up-regulating p18. However, intermittent hypoxic condition could inhibit A-549 cells invasion and promote cell proliferation by affecting the expression of Claudin-7 and p18. We also confirm, using a small interfering RNA transfection technique (siRNA), that Claudin-7 could act as an anti-cancer biomarker of metastasis in A-549 cells. Silencing HIF-1α in A-549 cells could down-r.. View More»
DOI:
10.4172/2167-7700.1000231