Andrology-Open Access
Open Access

Yi Tang

Publications

• Research Article
  Analysis of Changes in Nitric Oxide Synthase Signaling in BB/WOR Diabetic Prostate
  Author(s): Carol A Podlasek, Christopher W Bond, Yi Tang, Lance Marr, Nicholas Angeloni, Douglas Wood, Kevin E McKenna and Kevin T McVaryCarol A Podlasek, Christopher W Bond, Yi Tang, Lance Marr, Nicholas Angeloni, Douglas Wood, Kevin E McKenna and Kevin T McVary
  
  Purpose: Diabetes is associated with increased lower urinary tract symptom (LUTS) severity. An underlying cause of LUTS is increased prostate smooth muscle tone. A critical regulator of prostate innervation and tone is nitric oxide (NO), produced by nitric oxide synthase (NOS). Since NO regulates proliferation and relaxation, and NOS signaling is altered in patients with LUTS, we propose that decreased NO in diabetic patients leads to increased LUTS. We examined this hypothesis by quantifying changes in NOS signaling in the BB/WOR diabetic rat prostate. Materials and Methods:Protein and RNA abundance and localization of NOS I, -II and -III were examined in control and diabetic BB rat prostate by Real time RT-PCR, Western, immunohistochemical analysis and in situ.Morphological changes w.. View More»
  DOI: 10.4172/2167-0250.1000101

  Abstract PDF

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