Journal of Proteomics & Bioinformatics
Open Access

Y.L Ramachandra

Publications

• Research Article
  Gene Expression Profiling of Tuberculous Meningitis
  Author(s): Ghantasala S. Sameer Kumar, Abhilash K. Venugopal, Lakshmi Dhevi N. Selvan, Arivusudar Marimuthu, Shivakumar Keerthikumar, Swapnali Pathare, Jyoti Bajpai Dikshit, Pramila Tata, Ramesh Hariharan, Thottethodi Subrahmanya Keshava Prasad, H. C. Harsha, Y.L Ramachandra, Anita Mahadevan, Raghothama Chaerkady, S. K. Shankar and Akhilesh PandeyGhantasala S. Sameer Kumar, Abhilash K. Venugopal, Lakshmi Dhevi N. Selvan, Arivusudar Marimuthu, Shivakumar Keerthikumar, Swapnali Pathare, Jyoti Bajpai Dikshit, Pramila Tata, Ramesh Hariharan, Thottethodi Subrahmanya Keshava Prasad, H. C. Harsha, Y.L Ramachandra, Anita Mahadevan, Raghothama Chaerkady, S. K. Shankar and Akhilesh Pandey
  
  Tuberculous meningitis (TBM) is a form of extra pulmonary tuberculosis that is associated with severe neurological deficits and a high mortality. Early diagnosis of TBM is a major challenge despite the availability of several diagnostic methods. Existing diagnostic methods and markers are inadequate for early diagnosis of TBM owing to poor specificity and sensitivity. DNA microarray technology permits high-throughput identification of differentially expressed genes. In order to identify molecules as candidate biomarkers for early diagnosis or as therapeutic targets in TBM, we carried out transcriptomic analysis of brain tissue using whole human genome oligonucleotide arrays. From this gene expression analysis, we identified 2,434 genes that were differentially expressed at least two-fold in TBM cases as compared to controls. The large majority of the differentially expressed genes enc.. View More»
  DOI: 10.4172/jpb.1000174

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