Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Yohannis Meseret Hambissa

Yohannis Meseret Hambissa
Kotebe University College,
P. O. Box 31248, Addis Ababa
Ethiopia

Publications
  • Research Article
    Viral Subtypes, Coreceptor Usage and Phylogenetic Relationships of Hiv-1 Isolates in Discordant Positive and Concordant Couples
    Author(s): Yohannis Meseret Hambissa, Yohannes Mengistu, Rawleigh C Howe, Tsehaynesh Messele and Dawit Wolday Yohannis Meseret Hambissa, Yohannes Mengistu, Rawleigh C Howe, Tsehaynesh Messele and Dawit Wolday

    Ethiopian HIV viruses were mainly HIV type C in all discordant positives and HIV/AIDS subjects. But other subtypes such as subtype A, B and recombinant A/G subtypes were also observed. Co-receptor utilization of discordant positive isolated viruses was both CCR5 and CXCR4 in equal proportion. The majority of HIV/AIDS patients used CXCR4, although about one third used CCR5 and a few also used dual co receptors. Our study showed that the majority of subtype C viruses were CXCR4/SI high/rapid subtype. And about one third was CCR5/NSI subtypes. The phylogenetic or evolutionary relationship showed that the majority of the viruses isolated from discordant positives showed sub clustering in one region and those isolated from concordant couples in another region, showing that discordant positive isolated viruses were evolving independently and were related with each other but this was not see.. View More»
    DOI: 10.4172/2155-9899.1000500

    Abstract PDF

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