Emergency Medicine: Open Access
Open Access
ISSN: 2165-7548
ISSN: 2165-7548
Research Article
A Preliminary Study to Predict the Ingested Dose of Doxylamine from its Plasma Concentration in the Korean Patients with Doxylamine Intoxication
Author(s): Seung-Woo Kim, Ju-Seop Kang, Yoo-Sin Park, Shin-Hee Kim, Hyun-Jin Kim, Min-A Kang and Do-Wan Kim
Seung-Woo Kim, Ju-Seop Kang, Yoo-Sin Park, Shin-Hee Kim, Hyun-Jin Kim, Min-A Kang and Do-Wan Kim
Background: Doxylamine succinate, over-the-counter antihistamine, is commonly used as a nighttime sleep-aid and is world-wide ingested in overdoses when one attempts a suicide because of its easy accessibility. The objective of this study was aimed to find out models to predict the ingested amount of doxylamine from its blood concentrations of thirty Korean patients with doxylamine intoxication.
Method: Thirty patients who were admitted to two emergency centers through Jul, 2006 to Jul, 2008 due to doxylamine overdose were recruited. In all patients, demographic information and clinical variables, arrival time to the hospital after doxylmamine overdose, amount of doxylamine ingested, and vomiting were evaluated.
Results: Of these thirty patients, average ingestion amount of doxylamine was 750 mg (range, 200~2500 mg.. View More»
DOI:
10.4172/2165-7548.1000133