Journal of Drug Metabolism & Toxicology
Open Access

Y.P. Sahni

Publications

• Research Article
  Effect of Withania somnifera (Ashwagandha) on the Pharmacokinetics of Amikacin: A Future Antimicrobial Polypharmacy
  Author(s): Parikshit R. Dahikar, Nitesh Kumar and Y.P. Sahni Parikshit R. Dahikar, Nitesh Kumar and Y.P. Sahni
  
  The pharmacokinetic study of Amikacin with interaction of W. somnifera was investigated after single administration of 10 mg/kg of Amikacin intravenously and 500 mg/kg of W. somnifera orally in six non-descript healthy buffalo calves. Estimation of concentration of Amikacin in plasma was carried out by microbiological assay technique (Agar gel diffusion technique) by using Escherichia coli (ATCC 25922) as test organism. Following a single administration of 10 mg/kg of Amikacin intravenously and 500 mg/kg of W. somnifera orally in six non-descript healthy buffalo calves, plasma concentration of Amikacin, at 1 min of combined administration of these drugs were 17.05 ± 0.28 ?g/ml. The effective therapeutic concentration of Amikacin (? 1.0 ?g/ml) was maintained up to 24 h with mean value of 1.86 ± 0.038 ?g/ml. The mean distribution half-life of phase 1 (t1/2 ?1), phase 2 (t1/2 ?2) and elimin.. View More»
  DOI: 10.4172/2157-7609.1000142

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