Cloning & Transgenesis
Open Access
ISSN: 2168-9849
ISSN: 2168-9849
Yue Zhang
Notre-Dame Hospital,
1560 Sherbrooke Street East, Pavillon DeSève, Room Y2625, Montreal, Quebec
Canada
Editorial
The Potential “Core” of Vitamin D Receptor and Vitamin D Hypothesis: Synthesis of Common Basis of Some Autoimmune Diseases and Associated Cancers via Autophagy
Author(s): Yue Zhang
Yue Zhang
Nutrigenomics may tell us how various nutrients interact with the genome and potentially cause alteration of gene expressions. One nutrient of particular interest is vitamin D, deficiency of which may lead to diseases in various human organ and muscle systems. Decoding the genetics of complex diseases such as autoimmune diseases and/ or cancers associated with the aging process is vital to understand the controversies the beneficial effects of vitamin D supplementation on these diseases. Based on comparative advantages of different model system and recent ChIPseq/ ChIP-chip studies, we previously proposed one novel insightful hypothesis: the genetic regulatory network of Vitamin D Receptor (VDR, homologue of DAF-12 in Caenorhabditis elegans) may act as a common basis in preventing some autoimmune diseases and associated cancers. Further, such diseases may burst up with polygenic genet.. View More»
DOI:
10.4172/2168-9849.1000e106