Journal of Clinical & Experimental Dermatology Research
Open Access

Yuhei Hamasaki

Publications

• Research Article
  Blockade of Interleukin-33 Attenuates Allergic Contact Dermatitis in Model Mice: Possible Mechanism via Eosinophil Infiltration
  Author(s): Kazuto Taniguchi, Shuichi Yamamoto, Emiko Hitomi, Yukiko Inada Kazuto Taniguchi, Shuichi Yamamoto, Emiko Hitomi, Yukiko Inada
  
  Background: Interleukin (IL)-33, a novel member of the IL-1 family, is mainly produced by epithelial cells and endothelial cells. Effects of IL-33 on allergic diseases have been reported. Allergic contact dermatitis is a clinical form of contact hypersensitivity that involves a delayed-type hypersensitivity reaction. We previously reported that IL-33 is induced by tumor necrosis factor-alpha and interferon-gamma in keratinocytes and plays a critical role in allergic contact dermatitis. However, the mechanism underlying how IL-33 is involved in the pathogenesis of allergic contact dermatitis is not fully understood. We investigated the role of IL-33 in allergic contact dermatitis using model mice. Methods: Allergic contact dermatitis model mice were generated. Epidermal thickness and eosinophil infiltration in the dermis were evaluated by his.. View More»
  DOI: 10.4172/2155-9554.1000183

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