Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Yuling Tang
The First Hospital of Changsha,
Indiana
Research Article
Neferine Attenuates Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells via TGF-β Signaling Pathway
Author(s): Xianglong Kong, Hui Li, Qi Hu, Yusheng Yan, Wenfang Tang, Yuling Tang and Zheyu Hu
Xianglong Kong, Hui Li, Qi Hu, Yusheng Yan, Wenfang Tang, Yuling Tang and Zheyu Hu
Background: Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive, and fatal interstitial lung disease with the characteristics of lung tissue damage and an enhancement in extracellular matrix (ECM). Alveolar epithelial cells (AMs) are major target cells that can directly promote to occurring of pulmonary fibrosis by acquisition of a mesenchymal phenotype through epithelial- mesenchymal transition (EMT). Neferine, a component of Chinese herbs, has been thought to be involved in anti-fibrotic activity in experimental lung fibrosis. However, its mechanism is not clear. In this study, we explore the regulation of neferine in TGF-β-induced EMT in lung fibrosis model and illustrate its mechanism of action.
Methods: The alveolar epithelial cell line A549 was stimulated with TGF-β1 with or without Neferine pretreatment in advan.. View More»
DOI:
10.4172/2167-7700.1000241