Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Yunping Zhu
State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine,
Beijing 102206
IR Iran
Research Article
Prelocabc: A Novel Predictor of Protein Sub-cellular Localization Using a Bayesian Classifier
Author(s): Yanqiong Zhang, Tao Li, Chunyuan Yang, Dong Li, Yu Cui, Ying Jiang, Lingqiang Zhang, Yunping Zhu and Fuchu HeYanqiong Zhang, Tao Li, Chunyuan Yang, Dong Li, Yu Cui, Ying Jiang, Lingqiang Zhang, Yunping Zhu and Fuchu He
Sub-cellular localization of proteins is crucial for the dynamic life of cells. Its ascertainment is an important step to elucidate proteins' biological functions. Various experimental and computational methods have been developed for this purpose. Using a Bayesian model, we integrated five sub-modules based on different protein features, such as homology, amino acid composition, sorting signals and functional motifs, to predict sub-cellular localization of non-plant eukaryotic protein. This method has higher accuracy and Matthew's correlation coefficient values than previous algorithms against five independent test datasets, and is able to predict efficiently nine major sub-cellular compartments for both single-localized and multiple-localized proteins. As an application, we also combined this method with the proteome mass-spectrum quantitative information, improving the performance .. View More»
DOI:
10.4172/jpb.1000165