Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
ISSN: 2165-8056
Yun-Yao Xie
China
Review Article
Genome Mining for Aflatoxin Biosynthesis
Author(s): Qing-Qing Zhi, Yun-Yao Xie and Zhu-Mei He
Qing-Qing Zhi, Yun-Yao Xie and Zhu-Mei He
Occurrence of aflatoxins in crops has vast impacts on human health. Therefore, the study of aflatoxin biosynthesis has become important. Previous studies have shown that the aflatoxin biosynthesis gene cluster and several genes, enzymes, and regulatory elements are involved in aflatoxin biosynthesis; however, the intricate metabolic regulatory networks of aflatoxin synthesis remain unclear. Rapid development of fungal genomics and other ?omics? empower us for genome mining, gene expression profiling, and gene regulation studies that could provide more comprehensive insights into the aflatoxin biosynthesis regulatory network and other secondary metabolisms in fungi. Here we review the recent advances in the field of genome sequencing of aflatoxin-producing fungi, application of genomics, transcriptomics, proteomics, metabolomics, and epigenetics in aflatoxin biosynthesis. In addition, mit.. View More»
DOI:
10.4172/2165-8056.1000108