Journal of Clinical & Experimental Dermatology Research
Open Access

Yurika Yamate

Publications

• Review Article
  GP91phox Play an Important Role in Long-term Ultraviolet a Irradiation-induced Photoaging-associated Changes of Collagen I and Metalloproteinase-1
  Author(s): Keiichi Hiramoto, Hiromi Kobayashi, Yurika Yamate and Eisuke F Sato Keiichi Hiramoto, Hiromi Kobayashi, Yurika Yamate and Eisuke F Sato
  
  Irradiation with long-term ultraviolet (UV) A induces photoaging. The mechanisms responsible for the skin structural changes induced by long-term UVA irradiation remain unknown. In this study, we targeted gp91phox and conducted analysis of the mechanism of the photoaging induced by UVA. Male C57BL/6j and gp91phox-knockout (gp91phox-/-) mice were used in this study. The dorsal skin was locally exposed to UVA after covering the remaining body surface with aluminum foil at a dose of 110 kJ/m2 using a FL20SBLB-A lamp for three times a week for 20 weeks. We unexpectedly found that the hypertrophy of a skin and the inovasion of the inflammatory cells were not induced in the UVA long-term radiation gp91phox-/- mice. The levels of plasma nitrogen oxide (NO2/NO3), tumor necrosis factor-α (TNF-α) and interleyukin-1 (IL-1) all increased following UVA irradiation in the C57BL/6j mice;.. View More»
  DOI: 10.4172/2155-9554.1000199

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