Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Yvonne Magnusson
Institute of Biomedicine, Sahgrenska Academy,
P.O. BOX 419, SE-405 30 Göteborg
Sweden
Research Article
A Polymorphism at Position +874 in The IFN-γ Gene is Associated with Susceptibility for Dilated Cardiomyopathy
Author(s): Erika Lindberg, Bert Andersson, Robert Eggertsen, Ernst Nyström and Yvonne MagnussonErika Lindberg, Bert Andersson, Robert Eggertsen, Ernst Nyström and Yvonne Magnusson
The etiology of idiopathic dilated cardiomyopathy (DCM) is largely unknown. One hypothesis is that immunological factors are responsible for disease development. Single nucleotide polymorphisms (SNP) at position +874 of the IFN-γ gene and at position -168 of the MHC2TA gene have previously been shown to associate with infl ammatory and autoimmune disorders. We analysed their possible infl uence on susceptibility and prognosis in patients with DCM. Genotypes were determined by real-time PCR in 442 patients and 425 controls. Genotype frequencies were found signifi cantly different between patients and controls for IFN-γ (p=0.029), but not for MHC2TA (p=0.26). In a logistic regression analysis, the high producing TT genotype of IFN-γ was signfi cantly more common in patients than controls (OR 1.55 [1.12-2.15], p=0.009). None of the polymorphisms had an infl uence on long-t.. View More»
DOI:
10.4172/2155-9899.1000101