Journal of Hematology & Thromboembolic Diseases
Open Access

Yvonne P.J. Bosch

Publications

• Review Article
  Monitoring of Haemostasis and Anticoagulation in Cardiopulmonary Bypass Patients
  Author(s): Yvonne P.J. Bosch, Patrick W. Weerwind, Baheramsjah Mochtar and Raed Al DieriYvonne P.J. Bosch, Patrick W. Weerwind, Baheramsjah Mochtar and Raed Al Dieri
  
  Patients undergoing cardiac surgery with cardiopulmonary bypass are at risk of increased blood loss and transfusion requirements. Contact of blood with the surgical wound and the artificial surfaces of the extra-corporeal circuit results in a coagulopathy. Haemodilution during cardiopulmonary bypass also aggravates the reduction of haemostatic factors even further. On the other hand, systemic anticoagulation using high dose unfractionated heparin challenges the adequate anticoagulant monitoring. The most frequently used test to monitor systemic anticoagulation is the whole blood activated clotting time. This has, however, proven not be a reliable test. Other haemostatic assays have their own advantages and disadvantages, but tools to monitor anticoagulation and haemostasis adequately during and after cardiopulmonary bypass are to date lacking and/or show only a weak association with c.. View More»
  DOI: 10.4172/2329-8790.1000179

  Abstract PDF

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