Journal of Cell Signaling
Open Access
ISSN: 2576-1471
+44 1223 790975
ISSN: 2576-1471
+44 1223 790975
Zahra Zakeri
Department of Biology, Queens College,
65-30 Kissena Blvd, Flushing, NY 11367
Tanzania
Research Article
The Flavonoid Quercetin Protects MDCK Cells against Toxicity of CPT by Induction of Autophagy
Author(s): Rozalina Abramov, Sounak Ghosh Roy, Joselyn Landazuri, Keivan Zandi, Richard A. Lockshin and Zahra ZakeriRozalina Abramov, Sounak Ghosh Roy, Joselyn Landazuri, Keivan Zandi, Richard A. Lockshin and Zahra Zakeri
In chemotherapy, two or more pharmaceuticals targeting different metabolic pathways are often combined in the expectation that they will synergize or function additively against the tumor. Flavonoids, typically polycyclic plant pigments, have many beneficial effects in humans, including being putatively anticancer, inducing apoptosis by undefined means. Camptothecin (CPT), a powerful chemotherapeutic natural product used in Chinese traditional medicine is a topoisomerase inhibitor. In this study, we investigated whether two recommended flavonoids from plants, baicalein and quercetin, affected the capability of CPT to kill cells. We exposed MDCK (Madin Darby Canine Kidneys) cells to each flavonoid in the presence or absence of CPT; the flavonoids themselves were very modestly toxic at 50-100 μg/ml. However, quercetin but not baicalein reduces cell death induced by CPT. The flavonoid.. View More»
DOI:
10.4172/2576-1471.1000196