Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Zehra Buyuktuncer
Faculty of Health Sciences, Department of Nutrition and Dietetics, 06100-Sihhiye, Ankara
Turkey
Research Article
The Interaction of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Pro12Ala Polymorphism and Dietary Fat Intake among Turkish Patients with Metabolic Syndrome: A Cross Sectional Study
Author(s): Zehra Buyuktuncer, Gulden Koksal, Selcuk Dagdelen, Pinar Ozdemir, Mehlika Isildak and Tomris Erbas
Zehra Buyuktuncer, Gulden Koksal, Selcuk Dagdelen, Pinar Ozdemir, Mehlika Isildak and Tomris Erbas
Background: The metabolic syndrome is a complex disorder which occurs as a result of the interaction between genetic and environmental factors. The interaction between the peroxisome proliferator-activated receptor gamma (PPARγ) Pro12Ala polymorphism and dietary fats has been proposed to act in the pathogenesis of syndrome. This study aimed to verify whether dietary nutrient intake interacts with the PPARγ Pro12Ala polymorphism to modulate the features of the syndrome.
Methods: A total of 150 patients with metabolic syndrome participated. All subjects underwent a clinical, anthropometrical, biochemical and nutritional assessment and analysis of Pro12Ala polymorphism of PPARγ genotype.
Results: The polymorphism was detected in 14% of the sample (1.3% AlaAla homozygote and 12.7% AlaPro heterozygote).. View More»
DOI:
10.4172/2161-1017.1000202